Colombia striker Jackson Martinez believes nullifying Peru's highly-rated strikeforce will be the key to success in Tuesday's World Cup qualifier in Barranquilla.

Colombia moved into second spot in the South American qualifying group after holding leaders Argentina to a creditable goalless draw in Buenos Aires on Friday night.

Keeping a clean sheet was no mean feat against a team boasting some of the best forwards on the planet, and now Martinez hopes his side can do the same against Peru's dangerous attacking trio of Claudio Pizarro, Jefferson Farfan and Paolo Guerrero.

"If we manage to stop the good forwards that Peru have, we won't have problems," said Martinez.

"The Peruvian forwards are strong and they are hopeful of performing well here, so we'll try to do our jobs."

Colombia coach Jose Pekerman will have to shuffle his pack for the match though after James Rodriguez was ruled out with an injury sustained against Argentina while captain Mario Yepes, Christian Zapata and Juan Guillermo Cuadrado all picked up suspensions.

Peru, meanwhile, make the trip to Barranquilla boosted by Friday's unexpected 1-0 win over an Ecuador side who had started the night in second spot, four points behind Argentina.

Pizarro's early goal lifted Peru on to 14 points, leaving them in sixth place and within touching distance of Venezuela in fifth, a spot which would earn the occupant a play-off against a CONCACAF nation.

Peru coach Sergio Markarian warned his players against relaxing though, saying: "This victory does not mean we are qualified for the World Cup.

"We want our players not to be satisfied with little things. This team have what it takes to be better in the qualification."

While Argentina will aim to consolidate their five-point lead with victory over third-placed Ecuador in Quito on Tuesday, Chile are looking to keep hold of the fourth and final automatic qualifying spot with victory over Bolivia in Santiago.

"The match against Bolivia will be the most important because (by winning) we'll have a better chance of making it in the World Cup," said defender Jose Rojas.

"We should not relax but work more intensively to get higher in the standings."

Chile will be without the suspended Mauricio Isla against a Bolivia side who have picked up just two points from their last three matches to lie second-bottom.

In Tuesday's other game, surprise packages Venezuela take on reigning Copa America champions Uruguay in Puerto Ordaz.

Uruguay are struggling down in seventh spot on 13 points, but a victory on Tuesday would see them draw level with their opponents.

Uruguay captain Diego Lugano, whose side have picked up just two points from their last six qualifiers, believes it is a must-win match for the Charruas, saying: "We must get over the bad results of the past by beating Venezuela and remaining in the race.

"We are in this situation because of our own mistakes and because we failed to make the most of the opportunities that we've had to win."