NSW star Jarryd Hayne has been ruled out of the rugby league State of Origin Series decider and replaced on the wing by Newcastle's James McManus.

Hayne was ruled out by team doctor Nathan Gibbs today after undergoing a medical check on his hamstring injury.

He hadn't played since tearing his hamstring while turning out for Parramatta just 48 hours after playing a starring role in Origin I on June 5.